Linking Disease Associations with Regulatory Information in the Human Genome - Companion website
Marc A. Schaub, Alan P. Boyle, Anshul Kundaje, Serafim Batzoglou, Michael Snyder, Stanford University

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rs174570

Associations

Study: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. [PMID:19060911]
First author: Aulchenko YS
Journal: Nat Genet
Date: 12/07/2008
Phenotype: Cholesterol, total
Study population: 22,562 individuals
Association P-value: 2 x 10-10
Odds ratio [95% confidence interval]: .09 [NR] s.d. increase
Gene: FADS2
Risk allele: G
Minor allele frequency (controls): 0.83

Study: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. [PMID:19060911]
First author: Aulchenko YS
Journal: Nat Genet
Date: 12/07/2008
Phenotype: HDL cholesterol
Study population: 21,412 individuals
Association P-value: 4 x 10-06
Odds ratio [95% confidence interval]: .06 [NR] s.d. increase
Gene: FADS2
Risk allele: G
Minor allele frequency (controls): 0.83

Study: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. [PMID:19060911]
First author: Aulchenko YS
Journal: Nat Genet
Date: 12/07/2008
Phenotype: LDL cholesterol
Study population: 17,797 individuals
Association P-value: 4 x 10-13
Odds ratio [95% confidence interval]: .11 [NR] s.d. increase
Gene: FADS2
Risk allele: G
Minor allele frequency (controls): 0.83

Lead SNP

rs174570
Position: chr11:61,597,212 (Open in UCSC Genome Browser)
Distance to nearest TSS: 34,051 bp
GENCODE v7 location: Intron
RegulomeDB Score: 2b - ChIP-seq peak + any motif + matched DNase Footprint + DNaseI-seq peak (Open in RegulomeDB)

Linkage disequilibrium region

Linkage disequilibrium threshold:
 - In all HapMap 2 populations: r2≥0.8 r2≥0.9 r2=1.0 
 - In the HapMap 2 CEU population r2≥0.8 r2≥0.9 r2=1.0 

No SNPs found for this LD threshold.




Credits:
This resource uses data from:
 - The NHGRI GWAS catalog (accessed August 10, 2011)
 - The ENCODE project
 - RegulomeDB
 - The HapMap project

Contact: marc.schaub AT cs.stanford.edu
Last modified: 2011-12-15 01:19:21
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